#AANAM — Phase 1b/2 Trial Of RG6206 in Boys With DMD Supports Safety, Positive Muscle Effects

RG6206 (BMS-986089), a blocker of muscle growth-inhibitor myostatin, is safe to use in boys with Duchenne muscular dystrophy (DMD), results from a Phase 1b/2 trial show. A Phase 2/3 trial of the drug (NCT03039686) is actively recruiting patients. Moreover, the results showed that the compound was able to reduce…

Simultaneously Inhibiting Three Proteins Can Increase Muscle Mass in Mice with Muscular Dystrophy, Study Shows

Simultaneously inhibiting three proteins can increase muscle mass, a finding that could help those with diseases such as muscular dystrophy and cancer that cause muscle deterioration, an Australian study reports. The study, “Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and…

Gene Therapy May Safely Counter Muscle Wasting Process in Muscular Dystrophy

Researchers have developed a new gene therapy for muscle wasting conditions, and are now working to bring into clinical use through a newly formed biotech venture. The study describing the method, “Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice,” published in the journal…