CAP-1002 is a cardiac cell therapy that is currently being investigated in clinical trials for the use of Duchenne muscular dystrophy (DMD)-related cardiomyopathy.
The therapy consists of allogenic cardiosphere-derived cells (CDCs), meaning it’s produced in a laboratory using heart tissue from a healthy donor and stored until required. When needed, it’s administered via infusion into a coronary artery.
Studies of CAP-1002 in mouse models found that the therapy could improve heart function and increase exercise tolerance. It also slowed down inflammation, scarring and oxidative stress on the heart. The current clinical trial is being conducted with 25 males with Duchenne MD and the six-month results were published in April where it was found to be safe and well tolerated. Those who had the therapy showed improvement in some cardiac and upper limb function tests compared to the control group. Find out more about CAP-1002 here.
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